Ontology highlight
ABSTRACT:
SUBMITTER: Sun QA
PROVIDER: S-EPMC3179127 | biostudies-other | 2011 Sep
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20110906 38
Physiological sensing of O(2) tension (partial O(2) pressure, pO(2)) plays an important role in some mammalian cellular systems, but striated muscle generally is not considered to be among them. Here we describe a molecular mechanism in skeletal muscle that acutely couples changes in pO(2) to altered calcium release through the ryanodine receptor-Ca(2+)-release channel (RyR1). Reactive oxygen species are generated in proportion to pO(2) by NADPH oxidase 4 (Nox4) in the sarcoplasmic reticulum, an ...[more]