Ontology highlight
ABSTRACT:
SUBMITTER: De Vivo I
PROVIDER: S-EPMC129433 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
De Vivo Immaculata I Huggins Gordon S GS Hankinson Susan E SE Lescault Pamela J PJ Boezen Marike M Colditz Graham A GA Hunter David J DJ
Proceedings of the National Academy of Sciences of the United States of America 20020906 19
Excessive estrogen stimulation unopposed by progesterone strongly predisposes to endometrial cancer. Because the antiproliferative effect of progesterone requires the progesterone receptor (PR), which exists in two isoforms, PR-A and -B, we reasoned that variants in the PR gene may predispose to endometrial cancer. We found six variable sites, including four polymorphisms in the hPR gene and five common haplotypes. One promoter region polymorphism, +331G/A, creates a unique transcription start s ...[more]