Ontology highlight
ABSTRACT:
SUBMITTER: Kim MH
PROVIDER: S-EPMC1295591 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Kim Myung Hee MH Choi Won-Chan WC Kang Hye Ok HO Lee Jong Suk JS Kang Beom Sik BS Kim Kyung-Jin KJ Derewenda Zygmunt S ZS Oh Tae-Kwang TK Lee Choong Hwan CH Lee Jung-Kee JK
Proceedings of the National Academy of Sciences of the United States of America 20051128 49
In many Gram-negative bacteria, including a number of pathogens such as Pseudomonas aeruginosa and Erwinia carotovora, virulence factor production and biofilm formation are linked to the quorum-sensing systems that use diffusible N-acyl-L-homoserine lactones (AHLs) as intercellular messenger molecules. A number of organisms also contain genes coding for lactonases that hydrolyze AHLs into inactive products, thereby blocking the quorum-sensing systems. Consequently, these enzymes attract intense ...[more]