Ontology highlight
ABSTRACT:
SUBMITTER: Suh MH
PROVIDER: S-EPMC1297677 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Suh Man-Hee MH Ye Ping P Zhang Mincheng M Hausmann Stéphane S Shuman Stewart S Gnatt Averell L AL Fu Jianhua J
Proceedings of the National Academy of Sciences of the United States of America 20051121 48
Fcp1 is an essential protein phosphatase that hydrolyzes phosphoserines within the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II). Fcp1 plays a major role in the regulation of CTD phosphorylation and, hence, critically influences the function of Pol II throughout the transcription cycle. The basic understanding of Fcp1-CTD interaction has remained ambiguous because two different modes have been proposed: the "dockingsite" model versus the "distributive" mechanism. H ...[more]