Ontology highlight
ABSTRACT:
SUBMITTER: Spagnol G
PROVIDER: S-EPMC6032326 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Spagnol Gaelle G Trease Andrew J AJ Zheng Li L Gutierrez Mirtha M Basu Ishika I Sarmiento Cleofes C Moore Gabriella G Cervantes Matthew M Sorgen Paul L PL
International journal of molecular sciences 20180524 6
Activation of Wnt signaling induces Connexin43 (Cx43) expression via the transcriptional activity of β-catenin, and results in the enhanced accumulation of the Cx43 protein and the formation of gap junction channels. In response to Wnt signaling, β-catenin co-localizes with the Cx43 protein itself as part of a complex at the gap junction plaque. Work from several labs have also shown indirect evidence of this interaction via reciprocal co-immunoprecipitation. Our goal for the current study was t ...[more]