Ontology highlight
ABSTRACT:
SUBMITTER: Grishok A
PROVIDER: S-EPMC1297700 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Grishok Alla A Sharp Phillip A PA
Proceedings of the National Academy of Sciences of the United States of America 20051115 48
Short RNA regulatory molecules, microRNAs, and short interfering RNAs participate in a range of developmental gene networks by base-pairing with their target sequences. Consistent with these findings, genes required for the biogenesis and function of short interfering RNAs and microRNAs, dicer (dcr-1 in Caenorhabditis elegans) and argonaute homologs, are essential for development in diverse organisms, including C. elegans. We demonstrate that genes required for the function of short RNAs synergi ...[more]