Ontology highlight
ABSTRACT:
SUBMITTER: Lacroix J
PROVIDER: S-EPMC1298952 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Lacroix Jérôme J Poët Mallorie M Maehrel Céline C Counillon Laurent L
EMBO reports 20040101 1
Eukaryotic cells constantly have to fight against internal acidification. In mammals, this task is mainly performed by the ubiquitously expressed electroneutral Na(+)/H(+) exchanger NHE-1, which activates in a cooperative manner when cells become acidic. Despite its biological importance, the mechanism of this activation is still poorly understood, the most commonly accepted hypothesis being the existence of a proton-sensor site on the internal face of the transporter. This work uncovers mutatio ...[more]