Ontology highlight
ABSTRACT:
SUBMITTER: Gulati P
PROVIDER: S-EPMC1299110 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Gulati Pawan P Markova Boyka B Göttlicher Martin M Böhmer Frank-D FD Herrlich Peter A PA
EMBO reports 20040709 8
UV irradiation causes inflammatory and proliferative cellular responses. We have proposed previously that these effects are, to a large extent, caused by the ligand-independent activation of several receptor tyrosine kinases due to the inactivation of their negative control elements, the protein tyrosine phosphatases (PTPs). We examined the mechanism of this inactivation and found that, in addition to reversible oxidation of PTPs, UV triggers a novel mechanism: induced degradation of PTPs by cal ...[more]