Ontology highlight
ABSTRACT:
SUBMITTER: Flores MJ
PROVIDER: S-EPMC1299159 | biostudies-literature | 2004 Oct
REPOSITORIES: biostudies-literature
Flores Maria Jose MJ Bidnenko Vladimir V Michel Bénédicte B
EMBO reports 20040917 10
Replication forks arrested by inactivation of the main Escherichia coli DNA polymerase (polymerase III) are reversed by the annealing of newly synthesized leading- and lagging-strand ends. Reversed forks are reset by the action of RecBC on the DNA double-strand end, and in the absence of RecBC chromosomes are linearized by the Holliday junction resolvase RuvABC. We report here that the UvrD helicase is essential for RuvABC-dependent chromosome linearization in E. coli polymerase III mutants, whe ...[more]