Ontology highlight
ABSTRACT:
SUBMITTER: Blastyak A
PROVIDER: S-EPMC2034406 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Blastyák András A Pintér Lajos L Unk Ildiko I Prakash Louise L Prakash Satya S Haracska Lajos L
Molecular cell 20071001 1
Lesions in the template DNA strand block the progression of the replication fork. In the yeast Saccharomyces cerevisiae, replication through DNA lesions is mediated by different Rad6-Rad18-dependent means, which include translesion synthesis and a Rad5-dependent postreplicational repair pathway that repairs the discontinuities that form in the DNA synthesized from damaged templates. Although translesion synthesis is well characterized, little is known about the mechanisms that modulate Rad5-depe ...[more]