Ontology highlight
ABSTRACT:
SUBMITTER: Atilgan AR
PROVIDER: S-EPMC1303839 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Atilgan Ali Rana AR Atilgan Ali Rana AR Akan Pelin P Baysal Canan C
Biophysical journal 20040101 1 Pt 1
It is not merely the position of residues that is critically important for a protein's function and stability, but also their interactions. We illustrate, by using a network construction on a set of 595 nonhomologous proteins, that regular packing is preserved in short-range interactions, but short average path lengths are achieved through some long-range contacts. Thus, lying between the two extremes of regularity and randomness, residues in folded proteins are distributed according to a "small ...[more]