Transcriptomics

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Functional significance of the HIV-1 Tat signature amino acid residues


ABSTRACT: We sequenced the mRNA from a stably transduced Human T-cell line expressing the HIV-1 Tat protein. The inducible Tat expression has been used to understand and compare the cellular molecules and pathways being modulated by the wild type subtype-C Tat versus its single signature amino acid residue variant. Additionaly, the HIV-1 subtype B and C Tat comparitive analysis has also been included in the study to evaluate the gene expression profile as a reponse to subtype specific Tat proteins.

ORGANISM(S): Homo sapiens

PROVIDER: GSE89266 | GEO | 2018/10/25

REPOSITORIES: GEO

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