Ontology highlight
ABSTRACT:
SUBMITTER: Kim S
PROVIDER: S-EPMC1304489 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Biophysical journal 20040801 2
The nicotinic acetylcholine receptor is a neurotransmitter-gated ion channel in the postsynaptic membrane. It is composed of five homologous subunits, each of which contributes one transmembrane helix--the M2 helix--to create the channel pore. The M2 helix from the delta subunit is capable of forming a channel by itself. Although a model of the receptor was recently proposed based on a low-resolution, cryo-electron microscopy density map, we found that the model does not explain much of the othe ...[more]