Ontology highlight
ABSTRACT:
SUBMITTER: Dhara M
PROVIDER: S-EPMC7271128 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nature communications 20200603 1
Small molecule polyamines are abundant in all life forms and participate in diverse aspects of cell growth and differentiation. Spermidine/spermine acetyltransferase (SAT1) is the rate-limiting enzyme in polyamine catabolism and a primary genetic risk factor for suicidality. Here, using genome-wide screening, we find that SAT1 selectively controls nicotinic acetylcholine receptor (nAChR) biogenesis. SAT1 specifically augments assembly of nAChRs containing α7 or α4β2, but not α6 subunits. Polyami ...[more]