The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.
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ABSTRACT:
SUBMITTER: Colombo R
PROVIDER: S-EPMC1307602 | biostudies-literature | 2002 Nov
REPOSITORIES: biostudies-literature
Publications
The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.
Colombo Riccardo R Boggio Roberto R Seiser Christian C Draetta Giulio F GF Chiocca Susanna S
EMBO reports 20021022 11
The adenovirus early gene product Gam1 is crucial for virus replication and induces certain cellular genes by inactivating histone deacetylase 1 (HDAC1). We demonstrate that Gam1 (i) destroys promyelocitic leukemia nuclear bodies, (ii) delocalizes SUMO-1 into the cytoplasm and (iii) influences the SUMO-1 pathway. In addition, we show that Gam1 counteracts HDAC1 sumoylation both in vivo and in vitro. Sumoylation of HDAC1 does not seem to be absolutely required for HDAC1 biological activity but is ...[more]
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