Ontology highlight
ABSTRACT:
SUBMITTER: Frost SD
PROVIDER: S-EPMC1310509 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Frost Simon D W SD Wrin Terri T Smith Davey M DM Kosakovsky Pond Sergei L SL Liu Yang Y Paxinos Ellen E Chappey Colombe C Galovich Justin J Beauchaine Jeff J Petropoulos Christos J CJ Little Susan J SJ Richman Douglas D DD
Proceedings of the National Academy of Sciences of the United States of America 20051209 51
HIV type 1 (HIV-1) can rapidly escape from neutralizing antibody responses. The genetic basis of this escape in vivo is poorly understood. We compared the pattern of evolution of the HIV-1 env gene between individuals with recent HIV infection whose virus exhibited either a low or a high rate of escape from neutralizing antibody responses. We demonstrate that the rate of viral escape at a phenotypic level is highly variable among individuals, and is strongly correlated with the rate of amino aci ...[more]