Ontology highlight
ABSTRACT:
SUBMITTER: Eimer S
PROVIDER: S-EPMC131058 | biostudies-literature | 2002 Nov
REPOSITORIES: biostudies-literature
Eimer S S Lakowski B B Donhauser R R Baumeister R R
The EMBO journal 20021101 21
Presenilins are part of a protease complex that is responsible for the intramembraneous cleavage of the amyloid precursor protein involved in Alzheimer's disease and of Notch receptors. In Caenorhabditis elegans, mutations in the presenilin sel-12 result in a highly penetrant egg-laying defect. spr-5 was identified as an extragenic suppressor of the sel-12 mutant phenotype. The SPR-5 protein has similarity to the human polyamine oxidase-like protein encoded by KIAA0601 that is part of the HDAC-C ...[more]