Ontology highlight
ABSTRACT:
SUBMITTER: Westlund B
PROVIDER: S-EPMC26813 | biostudies-literature | 1999 Mar
REPOSITORIES: biostudies-literature
Westlund B B Parry D D Clover R R Basson M M Johnson C D CD
Proceedings of the National Academy of Sciences of the United States of America 19990301 5
Mutations in the human presenilin genes PS1 and PS2 cause early-onset Alzheimer's disease. Studies in Caenorhabditis elegans and in mice indicate that one function of presenilin genes is to facilitate Notch-pathway signaling. Notably, mutations in the C. elegans presenilin gene sel-12 reduce signaling through an activated version of the Notch receptor LIN-12. To investigate the function of a second C. elegans presenilin gene hop-1 and to examine possible genetic interactions between hop-1 and se ...[more]