Ontology highlight
ABSTRACT:
SUBMITTER: Dumortier A
PROVIDER: S-EPMC1317628 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Dumortier Alexis A Jeannet Robin R Kirstetter Peggy P Kleinmann Eva E Sellars MacLean M dos Santos Nuno R NR Thibault Christelle C Barths Jochen J Ghysdael Jacques J Punt Jennifer A JA Kastner Philippe P Chan Susan S
Molecular and cellular biology 20060101 1
The Ikaros transcription factor is both a key regulator of lymphocyte differentiation and a tumor suppressor in T lymphocytes. Mice carrying a hypomorphic mutation (Ik(L/L)) in the Ikaros gene all develop thymic lymphomas. Ik(L/L) tumors always exhibit strong activation of the Notch pathway, which is required for tumor cell proliferation in vitro. Notch activation occurs early in tumorigenesis and may precede transformation, as ectopic expression of the Notch targets Hes-1 and Deltex-1 is detect ...[more]