Ontology highlight
ABSTRACT:
SUBMITTER: Mayer H
PROVIDER: S-EPMC1317641 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Mayer Harald H Duit Sarah S Hauser Christoph C Schneider Wolfgang J WJ Nimpf Johannes J
Molecular and cellular biology 20060101 1
The Reelin signaling pathway operates in migrating neurons and is indispensable for their correct positioning during embryonic brain development. Many biochemical and cell biological studies to dissect the Reelin pathway at the molecular level are hampered by the lack of a cell line harboring a functional Reelin signaling pathway. Here we present fibroblast cell lines in which all required functional components of the pathway have been reconstituted. These cells react upon Reelin treatment in th ...[more]