New maximum likelihood estimators for eukaryotic intron evolution.
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ABSTRACT:
SUBMITTER: Nguyen HD
PROVIDER: S-EPMC1323467 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Publications
New maximum likelihood estimators for eukaryotic intron evolution.
Nguyen Hung D HD Yoshihama Maki M Kenmochi Naoya N
PLoS computational biology 20051230 7
The evolution of spliceosomal introns remains poorly understood. Although many approaches have been used to infer intron evolution from the patterns of intron position conservation, the results to date have been contradictory. In this paper, we address the problem using a novel maximum likelihood method, which allows estimation of the frequency of intron insertion target sites, together with the rates of intron gain and loss. We analyzed the pattern of 10,044 introns (7,221 intron positions) in ...[more]
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