Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins.

ABSTRACT: Serine/arginine-rich (SR) splicing factors play an important role in constitutive and alternative splicing as well as during several steps of RNA metabolism. Despite the wealth of functional information about SR proteins accumulated to-date, structural knowledge about the members of this family is very limited. To gain a better insight into structure-function relationships of SR proteins, we performed extensive sequence analysis of SR protein family members and combined it with ordered/disordered structure predictions. We found that SR proteins have properties characteristic of intrinsically disordered (ID) proteins. The amino acid composition and sequence complexity of SR proteins were very similar to those of the disordered protein regions. More detailed analysis showed that the SR prote

SUBMITTER: Haynes C 

PROVIDER: S-EPMC1326245 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature