Project description:Wolbachia pipientis is an obligate intracellular bacterium capable of spreading itself through populations by manipulating the reproduction of its hosts. The Wolbachia strain wMelPop, which reduces longevity in Drosophila melanogaster, has been introduced into the Dengue virus mosquito vector, Aedes aegypti, as a strategy to reduce disease transmission. The infecting Wolbachia halve the lifespan of the mosquito and induce numerous behavioral and physiological abnormalities that reduce the ability of the mosquito to successfully obtain a blood meal. We aim to understand the mechanism underpinning these changes and hence have chosen to explore how Wolbachia may be interacting with the insects nervous and muscle tissue. We carried out a series whole genome profiling experiments based on head and muscle tissues to identify mosquito pathways affected by the microbe.
Project description:mRNA expression data were collected from patients with brain tumor to improve diagnostic of gliomas on molecular level. Keywords: survey
Project description:A post-traumatic partial tear of the flexor hallucis longus tendon at the master knot of Henry and the resultant fibrosis of the knot can result in pain at the medial foot arch or posteromedial ankle pain with trigger hallux. Open debridement of the master knot of Henry is indicated if the symptoms do not improve with nonoperative treatment. The open procedure requires extensive soft-tissue dissection because the master knot of Henry is a deep structure. Endoscopic release of the master knot of Henry is an alternative to the open procedure and has the advantage of less surgical trauma and potential for less chance of recurrence of fibrosis of the master knot of Henry.
Project description:The reactivity of C-CH? substituted N-protected aldimines in aza-Henry addition reactions was compared with that of the analogous trifluoromethylated compounds. C-Alkyl aldimines easily reacted with nitro alkanes under solvent-free conditions and in the absence of catalyst, despite being worse electrophiles than C-CF? aldimines, they gave the aza-Henry addition only when ZrCl? was added. The presence of a bulky group on the imine carbon deeply influenced the reactivity.