Ontology highlight
ABSTRACT:
SUBMITTER: Wiley RD
PROVIDER: S-EPMC1334656 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Wiley Rebecca D RD Gummuluru Suryaram S
Proceedings of the National Academy of Sciences of the United States of America 20060109 3
Immature dendritic cells (DCs) capture HIV type 1 (HIV-1) and can transmit captured virus particles to T cells. In this report, we show that HIV-1 particles captured by DCs can be transmitted to T cells by exocytosis without de novo infection. Captured HIV-1 particles were rapidly endocytosed to tetraspan protein (CD9, CD63)-positive endocytic compartments that were reminiscent of multivesicular endosomal bodies. Furthermore, some of the endocytosed virus particles were constitutively released i ...[more]