Ontology highlight
ABSTRACT:
SUBMITTER: Miksa M
PROVIDER: S-EPMC2787084 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Miksa Michael M Wu Rongqian R Dong Weifeng W Komura Hidefumi H Amin Dhruv D Ji Youxin Y Wang Zhimin Z Wang Haichao H Ravikumar Thanjavur S TS Tracey Kevin J KJ Wang Ping P
Journal of immunology (Baltimore, Md. : 1950) 20091007 9
Sepsis, a highly lethal systemic inflammatory syndrome, is associated with increases of proinflammatory cytokines (e.g., TNF-alpha, HMGB1) and the accumulation of apoptotic cells that have the potential to be detrimental. Depending on the timing and tissue, prevention of apoptosis in sepsis is beneficial; however, thwarting the development of secondary necrosis through the active removal of apoptotic cells by phagocytosis may offer a novel anti-sepsis therapy. Immature dendritic cells (IDCs) rel ...[more]