Ontology highlight
ABSTRACT:
SUBMITTER: Du XJ
PROVIDER: S-EPMC133731 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Du Xiao-Jun XJ Cole Timothy J TJ Tenis Nora N Gao Xiao-Ming XM Köntgen Frank F Kemp Bruce E BE Heierhorst Jörg J
Molecular and cellular biology 20020401 8
Ca(2+) signaling plays a central role in cardiac contractility and adaptation to increased hemodynamic demand. We have generated mice with a targeted deletion of the S100A1 gene coding for the major cardiac isoform of the large multigenic S100 family of EF hand Ca(2+)-binding proteins. S100A1(-/-) mice have normal cardiac function under baseline conditions but have significantly reduced contraction rate and relaxation rate responses to beta-adrenergic stimulation that are associated with a reduc ...[more]