Ontology highlight
ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC133741 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20020401 8
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase whose focal adhesion targeting (FAT) domain interacts with other focal adhesion molecules in integrin-mediated signaling. Localization of activated FAK to focal adhesions is indispensable for its function. Here we describe a solution structure of the FAT domain bound to a peptide derived from paxillin, a FAK-binding partner. The FAT domain is composed of four helices that form a "right-turn" elongated bundle; the globular fold is mainl ...[more]