Ontology highlight
ABSTRACT:
SUBMITTER: Bertolucci CM
PROVIDER: S-EPMC2279287 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Bertolucci Craig M CM Guibao Cristina D CD Zheng Jie J
Protein science : a publication of the Protein Society 20050202 3
The C-terminal region of focal adhesion kinase (FAK) consists of a right-turn, elongated, four-helix bundle termed the focal adhesion targeting (FAT) domain. The structure of this domain is maintained by hydrophobic interactions, and this domain is also the proposed binding site for the focal adhesion protein paxillin. Paxillin contains five well-conserved LD motifs, which have been implicated in the binding of many focal adhesion proteins. In this study we determined that LD4 binds specifically ...[more]