Ontology highlight
ABSTRACT:
SUBMITTER: Cote JF
PROVIDER: S-EPMC1352170 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Côté Jean-François JF Motoyama Andrea B AB Bush Jason A JA Vuori Kristiina K
Nature cell biology 20050717 8
The evolutionarily conserved DOCK180 protein has an indispensable role in cell migration by functioning as an exchange factor for Rac GTPase via its DOCK homology region (DHR)-2 domain. We report here that the conserved DHR-1 domain also has an important signalling role. A form of DOCK180 that lacks DHR-1 fails to promote cell migration, although it is capable of inducing Rac GTP-loading. The DHR-1 domain interacts with PtdIns(3,4,5)P(3) in vitro and in vivo, and mediates the DOCK180 signalling ...[more]