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ABSTRACT:
SUBMITTER: Takabayashi T
PROVIDER: S-EPMC2871484 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Takabayashi Tetsuji T Xie Min-Jue MJ Takeuchi Seiji S Kawasaki Motomi M Yagi Hideshi H Okamoto Masayuki M Tariqur Rahman M RM Malik Fawzia F Kuroda Kazuki K Kubota Chikara C Fujieda Shigeharu S Nagano Takashi T Sato Makoto M
The Journal of biological chemistry 20100317 21
Phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P(3)) accumulates at the leading edge of migrating cells and works, at least partially, as both a compass to indicate directionality and a hub for subsequent intracellular events. However, how PtdIns(3,4,5)P(3) regulates the migratory machinery has not been fully elucidated. Here, we demonstrate a novel mechanism for efficient lamellipodium formation that depends on PtdIns(3,4,5)P(3) and the reciprocal regulation of PtdIns(3,4,5)P(3) itself. ...[more]