Metalloendoprotease cleavage triggers gelsolin amyloidogenesis.
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ABSTRACT:
SUBMITTER: Page LJ
PROVIDER: S-EPMC1356312 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Publications
Metalloendoprotease cleavage triggers gelsolin amyloidogenesis.
Page Lesley J LJ Suk Ji Young JY Huff Mary E ME Lim Hee-Jong HJ Venable John J Yates John J Kelly Jeffery W JW Balch William E WE
The EMBO journal 20051110 23
Amyloid diseases like Alzheimer's disease and familial amyloidosis of Finnish type (FAF) stem from endoproteolytic cleavage of a precursor protein to generate amyloidogenic peptides that accumulate as amyloid deposits in a tissue-specific manner. FAF patients deposit both 8 and 5 kDa peptides derived from mutant (D187Y/N) plasma gelsolin in the extracellular matrix (ECM). The first of two aberrant sequential proteolytic events is executed by furin to yield a 68 kDa (C68) secreted fragment. We no ...[more]
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