Both R5 and X4 human immunodeficiency virus type 1 variants persist during prolonged therapy with five antiretroviral drugs.
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ABSTRACT:
SUBMITTER: van Rij RP
PROVIDER: S-EPMC136002 | biostudies-literature | 2002 Mar
REPOSITORIES: biostudies-literature
Publications
Both R5 and X4 human immunodeficiency virus type 1 variants persist during prolonged therapy with five antiretroviral drugs.
van Rij Ronald P RP Visser Janny A JA van Praag Rieneke M E RM Rientsma Ronald R Prins Jan M JM Lange Joep M A JM Schuitemaker Hanneke H
Journal of virology 20020301 6
A viral reservoir of human immunodeficiency virus type 1 (HIV-1)-infected, resting CD4(+) T cells persists despite suppression of plasma viremia by combination antiretroviral therapy. In a longitudinal analysis of three patients treated with a five-drug regimen, both R5 and X4 HIV-1 variants persisted in the cellular reservoir for up to 3 years. ...[more]
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