Ontology highlight
ABSTRACT:
SUBMITTER: Allen KP
PROVIDER: S-EPMC1360293 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Infection and immunity 20060201 2
Enterotoxigenic Escherichia coli (ETEC) infections are a significant cause of diarrheal disease and infant mortality in developing countries. Studies of ETEC pathogenesis relevant to vaccine development have been greatly hampered by the lack of a suitable small-animal model of infection with human ETEC strains. Here, we demonstrate that adult immunocompetent outbred mice can be effectively colonized with the prototypical human ETEC H10407 strain (colonization factor antigen I; heat-labile and he ...[more]