Ontology highlight
ABSTRACT:
SUBMITTER: Tokuhara D
PROVIDER: S-EPMC2889329 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Tokuhara Daisuke D Yuki Yoshikazu Y Nochi Tomonori T Kodama Toshio T Mejima Mio M Kurokawa Shiho S Takahashi Yuko Y Nanno Masanobu M Nakanishi Ushio U Takaiwa Fumio F Honda Takeshi T Kiyono Hiroshi H
Proceedings of the National Academy of Sciences of the United States of America 20100426 19
Cholera and enterotoxigenic Escherichia coli (ETEC) are among the most common causes of acute infantile gastroenteritis globally. We previously developed a rice-based vaccine that expressed cholera toxin B subunit (MucoRice-CTB) and had the advantages of being cold chain-free and providing protection against cholera toxin (CT)-induced diarrhea. To advance the development of MucoRice-CTB for human clinical application, we investigated whether the CTB-specific secretory IgA (SIgA) induced by MucoR ...[more]