Ontology highlight
ABSTRACT:
SUBMITTER: Wallny HJ
PROVIDER: S-EPMC1360531 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Wallny Hans-Joachim HJ Avila David D Hunt Lawrence G LG Powell Timothy J TJ Riegert Patricia P Salomonsen Jan J Skjødt Karsten K Vainio Olli O Vilbois Francis F Wiles Michael V MV Kaufman Jim J
Proceedings of the National Academy of Sciences of the United States of America 20060123 5
Compared with the MHC of typical mammals, the chicken MHC is smaller and simpler, with only two class I genes found in the B12 haplotype. We make five points to show that there is a single-dominantly expressed class I molecule that can have a strong effect on MHC function. First, we find only one cDNA for two MHC haplotypes (B14 and B15) and cDNAs corresponding to two genes for the other six (B2, B4, B6, B12, B19, and B21). Second, we find, for the B4, B12, and B15 haplotypes, that one cDNA is a ...[more]