Ontology highlight
ABSTRACT:
SUBMITTER: Shiryaev SA
PROVIDER: S-EPMC1360700 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Shiryaev Sergey A SA Ratnikov Boris I BI Chekanov Alexei V AV Sikora Sergey S Rozanov Dmitri V DV Godzik Adam A Wang Jun J Smith Jeffrey W JW Huang Ziwei Z Lindberg Iris I Samuel Melanie A MA Diamond Michael S MS Strongin Alex Y AY
The Biochemical journal 20060101 Pt 2
Mosquito-borne WNV (West Nile virus) is an emerging global threat. The NS3 proteinase, which is essential for the proteolytic processing of the viral polyprotein precursor, is a promising drug target. We have isolated and biochemically characterized the recombinant, highly active NS3 proteinase. We have determined that the NS3 proteinase functions in a manner that is distantly similar to furin in cleaving the peptide and protein substrates. We determined that aprotinin and D-arginine-based 9-12- ...[more]