Phosphonate inhibitors of West Nile virus NS2B/NS3 protease.
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ABSTRACT:
SUBMITTER: Skorenski M
PROVIDER: S-EPMC6211275 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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Phosphonate inhibitors of West Nile virus NS2B/NS3 protease.
Skoreński Marcin M Milewska Aleksandra A Pyrć Krzysztof K Sieńczyk Marcin M Oleksyszyn Józef J
Journal of enzyme inhibition and medicinal chemistry 20191201 1
West Nile virus (WNV) is a member of the flavivirus genus belonging to the Flaviviridae family. The viral serine protease NS2B/NS3 has been considered an attractive target for the development of anti-WNV agents. Although several NS2B/NS3 protease inhibitors have been described so far, most of them are reversible inhibitors. Herein, we present a series of α-aminoalkylphosphonate diphenyl esters and their peptidyl derivatives as potent inhibitors of the NS2B/NS3 protease. The most potent inhibitor ...[more]
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