Ontology highlight
ABSTRACT:
SUBMITTER: Paluch E
PROVIDER: S-EPMC1366569 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Paluch Ewa E Piel Matthieu M Prost Jacques J Bornens Michel M Sykes Cécile C
Biophysical journal 20050506 1
Cell shape and movements rely on complex biochemical pathways that regulate actin, microtubules, and substrate adhesions. Some of these pathways act through altering the cortex contractility. Here we examined cellular systems where contractility is enhanced by disassembly of the microtubules. We found that adherent cells, when detached from their substrate, developed a membrane bulge devoid of detectable actin and myosin. A constriction ring at the base of the bulge oscillated from one side of t ...[more]