Ontology highlight
ABSTRACT:
SUBMITTER: D'Andrea MM
PROVIDER: S-EPMC1366893 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20060201 2
We report multifocal detection (four different cities in northern Italy) of Proteus mirabilis isolates resistant to both oxyimino- and 7-alpha-methoxy-cephalosporins and producing a novel acquired AmpC-like beta-lactamase. The enzyme, named CMY-16, is a variant of the CMY/LAT lineage, which differs from the closest homologues, CMY-4 and CMY-12, by a single amino acid substitution (A171S or N363S, respectively) and from CMY-2 by two substitutions (A171S and W221R). Expression of the cloned bla(CM ...[more]