Identification of emergent bla CMY-2 -carrying Proteus mirabilis lineages by whole-genome sequencing.
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ABSTRACT:
SUBMITTER: Mac Aogain M
PROVIDER: S-EPMC4710684 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Identification of emergent bla CMY-2 -carrying Proteus mirabilis lineages by whole-genome sequencing.
Mac Aogáin M M Rogers T R TR Crowley B B
New microbes and new infections 20151127
Whole-genome sequencing of 24 Proteus mirabilis isolates revealed the clonal expansion of two cefoxitin-resistant strains among patients with community-onset infection. These strains harboured bla CMY-2 within a chromosomally located integrative and conjugative element and exhibited multidrug resistance phenotypes. A predominant strain, identified in 18 patients, also harboured the PGI-1 genomic island and associated resistance genes, accounting for its broader antibiotic resistance profile. The ...[more]
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