Ontology highlight
ABSTRACT:
SUBMITTER: Hu X
PROVIDER: S-EPMC1367013 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Hu Xinge X Ma Meiyun M Dahl Gerhard G
Biophysical journal 20051007 1
Gap junction channels are intercellular channels that mediate the gated transfer of molecules between adjacent cells. To identify the domain determining channel conductance, the first transmembrane segment (M1) was reciprocally exchanged between Cx46 and Cx32E(1)43. The resulting chimeras exhibited conductances similar to that of the respective M1 donor. Furthermore, a chimera with the carboxy-terminal half of M1 in Cx46 replaced by that of Cx32 exhibited a conductance similar to that of Cx32E(1 ...[more]