Extending a spectrin repeat unit. I: linear force-extension response.
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ABSTRACT:
SUBMITTER: Paramore S
PROVIDER: S-EPMC1367040 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Publications
Extending a spectrin repeat unit. I: linear force-extension response.
Paramore Sterling S Ayton Gary S GS Mirijanian Dina T DT Voth Gregory A GA
Biophysical journal 20051014 1
Nonequilibrium molecular dynamics simulations were used to calculate the elastic properties of a spectrin repeat unit. A contiguous alpha-helical linker was constructed by employing periodic boundary conditions, allowing a novel scheme for evaluating the thermodynamic force as a function of extension. By measuring the force-extension response under small extensions, spectrin was observed to behave primarily as an elastic material with a spring constant of 1700 +/- 100 pN/nm. The implications of ...[more]
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