Ontology highlight
ABSTRACT:
SUBMITTER: Kaku Y
PROVIDER: S-EPMC136790 | biostudies-literature | 2002 Nov
REPOSITORIES: biostudies-literature
Journal of virology 20021101 22
The teschoviruses constitute a recently defined picornavirus genus. Most of the genome sequence of the porcine teschovirus-1 (PTV) Talfan and several other strains is known. We now demonstrate that initiation of protein synthesis occurs at nucleotide (nt) 412 on the PTV Talfan RNA and that nt 1 to 405 contains an internal ribosome entry site (IRES) that functions efficiently in vitro and within mammalian cells. In comparison with other picornavirus IRES elements, the PTV IRES is relatively short ...[more]