Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt U
PROVIDER: S-EPMC136874 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
Schmidt Ulrike U Beyer Jörg J Polster Ulf U Gershwin Laurel J LJ Buchholz Ursula J UJ
Journal of virology 20021201 23
Recombinant bovine respiratory syncytial virus (rBRSV) and an rBRSV deletion mutant lacking the G gene (rBRSVDeltaG) were characterized in calves with respect to replication competence, attenuation, and protective efficacy as live-attenuated BRSV vaccines. Both recombinant viruses were safe and induced protection against a BRSV challenge infection. rBRSV replicated efficiently in the upper respiratory tract. Intranasal immunization with rBRSVDeltaG led to infection but not to mucosal virus repli ...[more]