Ontology highlight
ABSTRACT:
SUBMITTER: Makkerh JP
PROVIDER: S-EPMC1369184 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
EMBO reports 20051001 10
Target-derived neurotrophins regulate neuronal survival and growth by interacting with cell-surface tyrosine kinase receptors. The p75 neurotrophin receptor (p75 NTR) is coexpressed with Trk receptors in long-range projection neurons, in which it facilitates neurotrophin binding to Trk and enhances Trk activity. Here, we show that TrkA and TrkB receptors undergo robust ligand-dependent ubiquitination that is dependent on activation of the endogenous Trk activity of the receptors. Coexpression of ...[more]