Ontology highlight
ABSTRACT:
SUBMITTER: Mansilla A
PROVIDER: S-EPMC1369204 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Mansilla Alicia A López-Sánchez Carmen C de la Rosa Enrique J EJ García-Martínez Virginio V Martínez-Salas Encarna E de Pablo Flora F Hernández-Sánchez Catalina C
EMBO reports 20051201 12
Proinsulin gene expression regulation and function during early embryonic development differ remarkably from those found in postnatal organisms. The embryonic proinsulin protein content decreased from gastrulation to neurulation in contrast with the overall proinsulin messenger RNA increase. This is due to increasing levels of a proinsulin mRNA variant generated by intron 1 retention in the 5' untranslated region. Inclusion of intron 1 inhibited proinsulin translation almost completely without a ...[more]