Ontology highlight
ABSTRACT:
SUBMITTER: Esposito MV
PROVIDER: S-EPMC5187945 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Esposito Maria Valeria MV Nunziato Marcella M Starnone Flavio F Telese Antonella A Calabrese Alessandra A D'Aiuto Giuseppe G Pucci Pietro P D'Aiuto Massimiliano M Baralle Francisco F D'Argenio Valeria V Salvatore Francesco F
International journal of molecular sciences 20161221 12
About 10% of all breast cancers arise from hereditary mutations that increase the risk of breast and ovarian cancers; and about 25% of these are associated with the <i>BRCA1</i> or <i>BRCA2</i> genes. The identification of <i>BRCA1</i>/<i>BRCA2</i> mutations can enable physicians to better tailor the clinical management of patients; and to initiate preventive measures in healthy carriers. The pathophysiological significance of newly identified variants poses challenges for genetic counseling. We ...[more]