Ontology highlight
ABSTRACT:
SUBMITTER: Martin-Benito J
PROVIDER: S-EPMC136944 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
Martín-Benito Jaime J Boskovic Jasminka J Gómez-Puertas Paulino P Carrascosa José L JL Simons C Torrey CT Lewis Sally A SA Bartolini Francesca F Cowan Nicholas J NJ Valpuesta José M JM
The EMBO journal 20021201 23
The biogenesis of the cytoskeletal proteins actin and tubulin involves interaction of nascent chains of each of the two proteins with the oligomeric protein prefoldin (PFD) and their subsequent transfer to the cytosolic chaperonin CCT (chaperonin containing TCP-1). Here we show by electron microscopy that eukaryotic PFD, which has a similar structure to its archaeal counterpart, interacts with unfolded actin along the tips of its projecting arms. In its PFD-bound state, actin seems to acquire a ...[more]