Ontology highlight
ABSTRACT:
SUBMITTER: Tsui V
PROVIDER: S-EPMC1370417 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
RNA (New York, N.Y.) 20030501 5
We describe a novel procedure for generating and optimizing pattern descriptors that can be used to find structural motifs in DNA or RNA sequences. This combines a pattern-description language (based primarily on secondary structure alignment and conservation of some key nucleotides) with a scoring function that relies heavily on estimated folding free energies for the secondary structure of interest. For the cloverleaf secondary structure characteristic of tRNA, we show that a fairly simple pat ...[more]