Ontology highlight
ABSTRACT:
SUBMITTER: Grandvaux N
PROVIDER: S-EPMC137057 | biostudies-literature | 2002 Jun
REPOSITORIES: biostudies-literature
Grandvaux Nathalie N Servant Marc J MJ tenOever Benjamin B Sen Ganes C GC Balachandran Siddarth S Barber Glen N GN Lin Rongtuan R Hiscott John J
Journal of virology 20020601 11
Ubiquitously expressed interferon regulatory factor 3 (IRF-3) is directly activated after virus infection and functions as a key activator of the immediate-early alpha/beta interferon (IFN) genes, as well as the RANTES chemokine gene. In the present study, a tetracycline-inducible expression system expressing a constitutively active form of IRF-3 (IRF-3 5D) was combined with DNA microarray analysis to identify target genes regulated by IRF-3. Changes in mRNA expression profiles of 8,556 genes we ...[more]